What Doctors & Customers say...
"My name is Amy Pascale and I am a Licensed Veterinary Technician in a small animal practice in New York. My dog Odin is a 75 lb. Norwegian elkhound, who at 8.5 years of age had been on Prosamine for about one year. Now I have switched him to ProMotion. He has done wonderfully on both products, but has done exceptional on the ProMotion. His activity level has increased and in turn he has lost some weight, which was much needed. I have no problem recommending this product to any of my clients, and those who have used it are happy with the results as well. I have no doubt that this product has given him a much better quality of life. Thank you!" "My vet put Charley (an 11-yr old mixed breed) on ProMotion as a dietary supplement. Now, like a miracle, Charley is his old self again! Running, leaping and wanting to play. I can't tell you how much joy it has brought us to see Charley feeling good again!" - John Hartsfield of Montgomery, AL "Both of my dogs and one of my horses are now on your products (ProMotion & ProMotion-EQ). I have a 4-yr old Chocolate Lab "Rio" who has had a sore knee in the past and she gets one tablet a day. Our other dog "Kodi" a 4-yr old Golden Retriever unfortunately has developed a bad knee. I have seen a tremendous difference in Kodi's mobility in the two months she has been on ProMotion. Our vet feels she needs to strengthen the ligaments prior to surgery and the Glucosamine level in your product is just right. My 13-yr old gelding just recently developed a problem in his stifle and the ProMotion-EQ has really helped with his mobility as well. Due to his age and previous racing career, I will keep him on the ProMotion-EQ. Having your products available to me has been great." - Lynn Kirchner from Carbondale, CO "My dog Rees (Rhodesian Ridgeback mix) was exhibiting clinical signs of hip dysplasia at the early age of 6-months old. He had reconstructive surgery, a triple pelvic osteotomy on the left hip by 7 months of age. The right hip was already too degenerated to do this surgery. This surgery helped and he was a happy dog for two years. He is now two and a half and recently began limping after exercise and would no longer jump up on my bed. He didn't show excitement about going for walks anymore. I started him on ProMotion two months ago, and already I see improvement. Rees is once again chasing after tennis balls and sleeping on my bed. I would recommend this product to my future patients." - Robin Jaeger, a 3rd year veterinary student at the University of Florida March 8, 2006 - "We wanted to thank you for making such a wonderful product. We have been using ProMotion for two years now. Over the past few years, our eight year old Chocolate Lab, Dudley, has gone through two TPLO surgeries for a ruptured ACL, as well as a Fibro Cartilaginous Embolism (FCE) to her spine last year. Due to these injuries, she has significant stiffness and occasional lameness. About six months ago, our vet suggested that we should begin physical therapy on her immediately and cut back on supplements and aspirin, to gain more strength in her back end. The physical therapy helped a great deal in her strength. Unfortunately, we noticed she was having a very hard time getting up and limping on her front legs. We didn't understand why this was happening, since she has been getting much stronger in her hind quarters. We then realized that we had taken her off of ProMotion! We immediately put her back on, and within about ten days, she was back to normal! There has been no need for aspirin, and she is happy again. We will make sure our vet knows about ProMotion. Thank you for making animals' lives a little better." - Scott and Claudia Culley "I definitely see the results in my 11-y.o. lab. She doesn't act her age at all with the ProMotion on board." - Tracy Marsh, RVT "I just wanted to say your ProMotion tablets have had a very positive effect on our 12-year old Lab/Husky mix. Prior to using your product, he was having a hard time moving around, especially up and down stairs. Our vet recommended ProMotion, and within 4 days we could see an improvement in his movement. That was 5 months ago and Randy now moves around like he did 6 years ago. We are certain this is a result of your product, because we ran out of tablets at one point and within 2 days, his old symptoms returned. Once ProMotion was returned to his diet, his good movement was back again. Thanks for helping our friend." - Rick & Barb, Illinois
"My name is Amy Pascale and I am a Licensed Veterinary Technician in a small animal practice in New York. My dog Odin is a 75 lb. Norwegian elkhound, who at 8.5 years of age had been on Prosamine for about one year. Now I have switched him to ProMotion. He has done wonderfully on both products, but has done exceptional on the ProMotion. His activity level has increased and in turn he has lost some weight, which was much needed. I have no problem recommending this product to any of my clients, and those who have used it are happy with the results as well. I have no doubt that this product has given him a much better quality of life. Thank you!" "My vet put Charley (an 11-yr old mixed breed) on ProMotion as a dietary supplement. Now, like a miracle, Charley is his old self again! Running, leaping and wanting to play. I can't tell you how much joy it has brought us to see Charley feeling good again!" - John Hartsfield of Montgomery, AL "Both of my dogs and one of my horses are now on your products (ProMotion & ProMotion-EQ). I have a 4-yr old Chocolate Lab "Rio" who has had a sore knee in the past and she gets one tablet a day. Our other dog "Kodi" a 4-yr old Golden Retriever unfortunately has developed a bad knee. I have seen a tremendous difference in Kodi's mobility in the two months she has been on ProMotion. Our vet feels she needs to strengthen the ligaments prior to surgery and the Glucosamine level in your product is just right. My 13-yr old gelding just recently developed a problem in his stifle and the ProMotion-EQ has really helped with his mobility as well. Due to his age and previous racing career, I will keep him on the ProMotion-EQ. Having your products available to me has been great." - Lynn Kirchner from Carbondale, CO "My dog Rees (Rhodesian Ridgeback mix) was exhibiting clinical signs of hip dysplasia at the early age of 6-months old. He had reconstructive surgery, a triple pelvic osteotomy on the left hip by 7 months of age. The right hip was already too degenerated to do this surgery. This surgery helped and he was a happy dog for two years. He is now two and a half and recently began limping after exercise and would no longer jump up on my bed. He didn't show excitement about going for walks anymore. I started him on ProMotion two months ago, and already I see improvement. Rees is once again chasing after tennis balls and sleeping on my bed. I would recommend this product to my future patients." - Robin Jaeger, a 3rd year veterinary student at the University of Florida March 8, 2006 - "We wanted to thank you for making such a wonderful product. We have been using ProMotion for two years now. Over the past few years, our eight year old Chocolate Lab, Dudley, has gone through two TPLO surgeries for a ruptured ACL, as well as a Fibro Cartilaginous Embolism (FCE) to her spine last year. Due to these injuries, she has significant stiffness and occasional lameness. About six months ago, our vet suggested that we should begin physical therapy on her immediately and cut back on supplements and aspirin, to gain more strength in her back end. The physical therapy helped a great deal in her strength. Unfortunately, we noticed she was having a very hard time getting up and limping on her front legs. We didn't understand why this was happening, since she has been getting much stronger in her hind quarters. We then realized that we had taken her off of ProMotion! We immediately put her back on, and within about ten days, she was back to normal! There has been no need for aspirin, and she is happy again. We will make sure our vet knows about ProMotion. Thank you for making animals' lives a little better." - Scott and Claudia Culley "I definitely see the results in my 11-y.o. lab. She doesn't act her age at all with the ProMotion on board." - Tracy Marsh, RVT "I just wanted to say your ProMotion tablets have had a very positive effect on our 12-year old Lab/Husky mix. Prior to using your product, he was having a hard time moving around, especially up and down stairs. Our vet recommended ProMotion, and within 4 days we could see an improvement in his movement. That was 5 months ago and Randy now moves around like he did 6 years ago. We are certain this is a result of your product, because we ran out of tablets at one point and within 2 days, his old symptoms returned. Once ProMotion was returned to his diet, his good movement was back again. Thanks for helping our friend." - Rick & Barb, Illinois
PROMOTION® (U.S. Patent No. 6,333,304)
- The original joint nutrient with bioflavanol antioxidants added to glucosamine and hydrolyzed collagen
- Only a 5-day loading dose
- Fast acting and effective - guaranteed!
- Highly palatable chewable tablets or sprinkle capsules for dogs and cats
Arthritis
Exercise trauma in working/sporting dogs
Degenerative joint disease
Heavy field trial work
Hip dysplasia
Post-operative care
Elbow dysplasia
Urinary tract disorders
Ununited anconeal process
ProMotion® includes glucosamine for joint health, bioflavanol (grape seed extract) to minimize both joint tissue deterioration and collagen degradation caused by elastase and collagenase enzymes and oxygen free radicals, and hydrolyzed collagen to regenerate cartilage. Glucosamine will activate chondrocytes in cartilage to produce more hyaluronic acid, which enters the ground substance of the tissue and maintains lubrication for cartilage regeneration. However, if amino acids, such as hydroxyproline, found in hydrolyzed collagen are not present in sufficient quantities, new cartilage will not be constructed. The anti-oxidative activity of bioflavanol is valuable in cases of joint deterioration. The beneficial effects are recognized as animals begin to move more freely. The synergistic balance of ProMotion® extends into the vitamin/mineral pack of vitamin C, manganese, cysteine, and zinc. Vitamin C is necessary for proper collagen synthesis and manganese is important for proteoglycan synthesis. Deficiencies of manganese can lead to bone loss, connective tissue fragility, and swollen joints. N-acetyl-cysteine is an important source of sulfur and supports the body's glutathione supply. Zinc is important for healing and as a coenzyme for metabolism. All four are excellent antioxidants and may control oxidative damage to connective tissue. Antioxidants are likely beneficial in joint-related conditions for several reasons. First, cartilage is avascular, anervic and alymphatic and the supply of nutrients to joint tissue is often not adequate to maintain normal cell regeneration or to regenerate damaged tissue. Daily free radical load and resulting oxidative damage are particularly destructive in joint tissue due to lack of sufficient blood supply. Injuries and trauma may also result in excessive generation of free radicals and even more joint tissue damage. ProMotion® is useful in post-operative care for ruptured anterior cruciate ligament (ACL) and in post-operative care for osteochondrosis dessicans (OCD) of the shoulder joint. Injury or surgery can cause free radical increases and therefore more cellular damage and inflammation. The antioxidants in ProMotion® help control further free radical damage and oxidative stress to the knee and shoulder joints. Another benefit of ProMotion® may be seen in urinary tract health. Glucosamine is a building block for glycosaminoglycans, which form a protective lining on the urinary tract wall. In feline and canine urinary infections, glycosaminoglycan levels are decreased and waste products are able to damage the urinary tract cells. In addition, bioflavanol prevents infectious agents such as E. coli from attaching to the urinary tract cells. ProMotion® has been shown in trials to benefit animals with joint problems. In one study of 63 dogs with osteoarthritis, pain scores were recorded for four common activities: walking, getting in/out of a car, walking on an incline, and squatting to defecate (Fig. 1). As illustrated, all resulted in marked improvement over a 90-day period.
Research:
1. Hawkins, Clare, and Michael J. Davies. "Oxidative Damage to Collagen and Related Substrates by Metal Ion/Hydrogen Peroxide Systems: Random Attack or Site-specific Damage?" Biochima et Biophysica Acta. 1360 (1997): 84-96.
2. Kuttan, R., et al. "Collagen Treated with (+)-Catechin Becomes Resistant to the Action of Mammalian Collagenase." Experimenta. 37 (1981).
3. Tixier, J. M. "Evidence by In Vitro Studies that Binding of Pycnogenols to Elastin Affects its Rate of Degradation by Elastases." Biochemical Pharmacology. 33.24 (1984): 3933-3939.
4. Karzel, K. and R. Domenjoz. "Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycan Metabolism of Fibroblast Cultures." Pharmacology. 5: 337-345 (1971).
5. Kim, J. and H. Conrad. "Effects of D-Glucosamine Concentration on the Kinetics of Mucopolysaccharide Biosynthesis in Cultured Chick Embryo Vertebral Cartilage." The Journal of Biological Chemistry. Vol. 249, No. 10, Issue of May 25, pp. 3091-3097 (1974).
1. Hawkins, Clare, and Michael J. Davies. "Oxidative Damage to Collagen and Related Substrates by Metal Ion/Hydrogen Peroxide Systems: Random Attack or Site-specific Damage?" Biochima et Biophysica Acta. 1360 (1997): 84-96.
2. Kuttan, R., et al. "Collagen Treated with (+)-Catechin Becomes Resistant to the Action of Mammalian Collagenase." Experimenta. 37 (1981).
3. Tixier, J. M. "Evidence by In Vitro Studies that Binding of Pycnogenols to Elastin Affects its Rate of Degradation by Elastases." Biochemical Pharmacology. 33.24 (1984): 3933-3939.
4. Karzel, K. and R. Domenjoz. "Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycan Metabolism of Fibroblast Cultures." Pharmacology. 5: 337-345 (1971).
5. Kim, J. and H. Conrad. "Effects of D-Glucosamine Concentration on the Kinetics of Mucopolysaccharide Biosynthesis in Cultured Chick Embryo Vertebral Cartilage." The Journal of Biological Chemistry. Vol. 249, No. 10, Issue of May 25, pp. 3091-3097 (1974).
Frequently Asked Questions
Q. What is the expected response time?
A. In a 90-day trial on 63 dogs, pain scores improved by 50% after just 10 days.
Q. Why is the loading dose only 5 days?
A: The bioflavanol in ProMotion® is key. Glycosaminoglycans (GAG's) such as glucosamine and chondroitin sulfate require 4-6 weeks to start being effective. Bioflavanol benefits joint pain and inflammation by scavenging free radicals in the joint. Research has shown that bioflavanol helps bind and strengthen collagen fibers, which provide structural support. These factors encourage faster response, which leads to a more economical and effective product.
Q. Why is there no chondroitin sulfate (CS) in the formula?
A: Bioflavanol prevents inflammation and enzymatic degradation in the joints and is absorbed more efficiently than CS. Also, supplementation with glucosamine has been shown to increase synthesis of chondroitin sulfate by 70%. When ingested, both glucosamine and CS ultimately promote the production of new CS in cartilage, but CS is molecularly too large to be immediately effective, while glucosamine is highly bioavailable and stimulatory. CS is also more expensive than the combination of glucosamine and bioflavanol.
Q: Are label claims guaranteed?
A: We employ a national independent laboratory to perform post-production analyses on our products. With this extra quality control measure, we can ensure label claims and guarantee safety.
