What Doctors & Customers say...
September 28, 2010 - "Thank you for the sample bottle of ProNeurozone. After approximately 3 weeks, the 17 yr old Australian Shepherd is vocalizing less at night. He is still waking and restless although less agitated. I'll keep you posted." - Dr. Simpson
September 17, 2010 - "It took about 5 days, but I really noticed the difference in my 12 year old dog with ProNeurozone. I will be ordering more. Thank you."
- Mary Lou Woodward, RVT, Culver City, CA Oct 24, 2007 - "I have used ProNeurozone on my 13-yr old dog. I took her off Anipryl and have noticed improvement in her responsiveness. Thanks, Joan Hankins, DVM" October 23, 2007 - "We received the sample of ProNeurozone and started it on Brett, the almost 14-year-old Border collie, right away. She loves the tablets! My husband and I were both very impressed with your questionnaire. Although I am a Vet Tech and Doug and I have both dealt extensively with our elderly parents and their health issues, we realized that we had never really considered which issues were probably cognitive and which were more likely to be structural. The questionnaire really helped us adjust our focus and is also a super way to get customers to quantify benefits. As for Brett, at the 30-day mark, we have noted very slight improvements on a few of the issues that we felt were more related to her mentation. Unfortunately, a urinalysis following some inappropriate urination shows a lot of transitional cells, and the antibody test gives a high likelihood of transitional cell carcinoma. Still, at her age, every contribution to quality of life helps, and so we are glad for the ProNeurozone! Thank you!"
- Kristi Murdock, RVT, Toddville, IA July 26, 2007 - "My 18-year old cat is more alert and active since I started her on ProNeurozone. I have recommended the product to several colleagues."
- Dr. McNeese, Albuquerque, NM Jan 26, 2007 - "I started my dogs on ProNeurozone a couple months ago. My Jack Russell will be 17-years old in April and had not really been having significant cognitive dysfunction, but I thought the ProNeurozone would be good for her just due to her age. She had shown some slight slowness to recognize me and my husband when we returned home from work, etc. but nothing major. She does now seem more alert quicker after waking up. I guess I can't say I see vast improvements, since she wasn't having a lot of problems before, but I am happy with how she is doing on the product. I had also put her on ProMotion in June of 2006 since she has some back and neck pain. She showed a dramatic improvement in a short period of time. Some days she runs around the house like she is very young again. I will certainly continue using ProMotion and probably the ProNeurozone too. Thank you very much for these fine products and I will recommend them to others. Sincerely, Dorothy, LVMT" Dr. Rodriguez of Warren, NJ reported using ProNeurozone on her own cat with success. When the cat gets ProNeurozone, she doesn't urinate outside her litter box. Without ProNeurozone, she does. June 6, 2005 - "I have had my 13-year old Shih Tzu on ProNeurozone for 60 days. The change in his cognitive function is amazing. He used to stare blankly into space and now he wants to play and bark. I am so impressed that I am bringing the line into our clinic to sell. Thanks for the samples - they really are convincing. I also use Proanthozone for his arthritis and allergies."
- Debbie Boone, Hospital Administrator at Cobb Animal Clinic, Greensboro, N.C.
- Mary Lou Woodward, RVT, Culver City, CA Oct 24, 2007 - "I have used ProNeurozone on my 13-yr old dog. I took her off Anipryl and have noticed improvement in her responsiveness. Thanks, Joan Hankins, DVM" October 23, 2007 - "We received the sample of ProNeurozone and started it on Brett, the almost 14-year-old Border collie, right away. She loves the tablets! My husband and I were both very impressed with your questionnaire. Although I am a Vet Tech and Doug and I have both dealt extensively with our elderly parents and their health issues, we realized that we had never really considered which issues were probably cognitive and which were more likely to be structural. The questionnaire really helped us adjust our focus and is also a super way to get customers to quantify benefits. As for Brett, at the 30-day mark, we have noted very slight improvements on a few of the issues that we felt were more related to her mentation. Unfortunately, a urinalysis following some inappropriate urination shows a lot of transitional cells, and the antibody test gives a high likelihood of transitional cell carcinoma. Still, at her age, every contribution to quality of life helps, and so we are glad for the ProNeurozone! Thank you!"
- Kristi Murdock, RVT, Toddville, IA July 26, 2007 - "My 18-year old cat is more alert and active since I started her on ProNeurozone. I have recommended the product to several colleagues."
- Dr. McNeese, Albuquerque, NM Jan 26, 2007 - "I started my dogs on ProNeurozone a couple months ago. My Jack Russell will be 17-years old in April and had not really been having significant cognitive dysfunction, but I thought the ProNeurozone would be good for her just due to her age. She had shown some slight slowness to recognize me and my husband when we returned home from work, etc. but nothing major. She does now seem more alert quicker after waking up. I guess I can't say I see vast improvements, since she wasn't having a lot of problems before, but I am happy with how she is doing on the product. I had also put her on ProMotion in June of 2006 since she has some back and neck pain. She showed a dramatic improvement in a short period of time. Some days she runs around the house like she is very young again. I will certainly continue using ProMotion and probably the ProNeurozone too. Thank you very much for these fine products and I will recommend them to others. Sincerely, Dorothy, LVMT" Dr. Rodriguez of Warren, NJ reported using ProNeurozone on her own cat with success. When the cat gets ProNeurozone, she doesn't urinate outside her litter box. Without ProNeurozone, she does. June 6, 2005 - "I have had my 13-year old Shih Tzu on ProNeurozone for 60 days. The change in his cognitive function is amazing. He used to stare blankly into space and now he wants to play and bark. I am so impressed that I am bringing the line into our clinic to sell. Thanks for the samples - they really are convincing. I also use Proanthozone for his arthritis and allergies."
- Debbie Boone, Hospital Administrator at Cobb Animal Clinic, Greensboro, N.C.
PRONEUROZONE ®
- Complete antioxidant/vitamin formula for senior dogs and cats
- Flavored, chewable tablet for dogs
- Sprinkle capsule flavored especially for cats
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Figure 1 - The percentage of older dogs in two age ranges exhibiting age-related behavioral impairment. The changes could occur in 4 categories: orientation, social interaction, house training, and sleep-wake cycle. The increase of occurrences with age is illustrated.
Reference: Neilson JC, Hart BL, Cliff KD, Ruehl WW. Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association. 2001 Jun 1;218(11):1787-91.
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Figure 2 - The percentage of older cats in two age ranges demonstrating clinical signs of cognitive dysfunction syndrome. Changes in social interaction were most commonly reported in cats aged 11-14 years. In cats aged 15 or more years, an altered sleep-wake cycle (e.g. nighttime vocalization) was the most common sign. The increase in prevalence within the older population is illustrated.
Reference: Moffat K, Landsberg G. An investigation of the prevalence of clinical signs of cognitive dysfunction syndrome (CDS) in cats. Proceedings of the American College of Veterinary Behaviorists. July 2003.
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Frequently Asked Questions
Q. What is the blood-brain barrier?
A: The blood-brain barrier (BBB) is a specialized system of capillary cells that determine which substances in the blood stream may pass into the brain. The BBB protects the brain from harmful substances. However, this barrier also presents a rate-limiting factor for the passing through of therapeutic drugs and beneficial nutrients into the brain.
Q. What are the behavioral signs of cognitive decline?
A: According to 48% of owners, dogs that are 8-years of age or older display at least one sign of cognitive dysfunction. Behavioral changes associated with age-related cognitive decline include:
- regressions in house training, orientation, and social interaction
- changes in sleeping and eating patterns
- fear or anxiety not previously exhibited
- increased or repetitive activity or vocalization
- decreased responsiveness to known commands and activities
